Fanhong Wu, Ph.D.
Professor
86-21-64941286
Dean of
School of Chemical and Environmental Engineering
Director, Institute of pharmaceutical Innovation (IPI)
Fellow, American Chemical Society
Senior member, Chinese Pharmaceutical Associate
Senior member, Chinese chemical Associate
Research Areas:
1. Synthesis, design, and biological evaluation of fluorine-containing bio-active compounds.
2. New drug discoveries.
3. New process studies of genetic drugs and drug intermediates.
4. Development of fine chemicals.
Education
1985.9-1989.7: Fudan University, B.S.
1989.9-1992.7: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, M.S.
1992.9-1995.6: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Ph. D.
Professional Experience
1995.7-1997.6: Postdoctoral fellow, Fudan University.
1997.7-2002.11: Associate professor of School of Chemistry and Molecular Engineering, East China University of Science and Technology
2002.12-2009.8: Professor of School of Chemistry and Molecular Engineering, East China University of Science and Technology
2009.09-Now: Dean of the school of Chemical and Environmental Engineering, Shanghai Institute of Technology
2010.04-Now：Director of Institute of Pharmaceutical Innovation, Shanghai Institute of Technology
Awards & Professional Activities
2002, Third grade award of excellent teacher of graduate course teaching
2003, Supervisor of a graduate student who won the third grade prize of the second Jiageng Chen invention (Shanghai) adolescent award
2007, Third award of technology invention-Shanghai science and technology awards
2009, Gold award of 22nd Shanghai excellent invention
Representative works:
2005 advanced organic chemistry - reaction and mechanism <East China university of science and technology Press ISBN: 9787562816775>
2006 Organic chemistry learning and postgraduate exams guidance < East China university of science and technology Press ISBN: 7-5628-1771-5>
Selected Publications:
1. Fanhua Xiao, Fanhong Wu, Yongjia Shen, Lifang Zhou, “Synthesis of α,α-difluoro-γ-butyrolactones via ethyl iododifluoroacetate”, J. Fluorine Chem., 2005, 126, 63-67.
2. Fanhua Xiao, Fanhong Wu, Xueyan Yang, Yongjia Shen, Xinmei Shi, “A convenient synthesis of fluoroalkylated γ-butyrolactones fron polyfluoroalkyl iodides and 4-pentenoic acid catalyzed by Pd(PPh3)4”, J. Fluorine Chem., 2005, 126, 319-323.
3. Shengjie Mao, Xiang Fang, Lu Ba, Fanhong Wu, The reaction of fluorine-containing compounds with conjugated dienoic acids initiated by sodium dithionite , J. Fluorine Chem. 2007, 128, 5-11.
4. Fanhong wu, Xueyan yang, zhonghua wang, Studies on sulfinatodehalogenation: The addition of polyfluoroalkyl iodides to olefins promoted by sodium bisulfite and sodium sulfite, J. Fluorine Chem. 2007,128, 84-86.
5. Xueyan Yang, Yaoping Zhu, Xiang Fang, Xianjin Yang, Fanhong Wu, Yongjia Shen, Synthesis of γ-butyrolactones containing α,α-difluoromethylenyl bisphosphonate initiated by Na2S2O4, J. Fluorine Chem. 2007, 128, 174-178.
6. Xianjin Yang, Wenjiao Yuan, Song Gu, Xueyan Yang, Fanhua Xiao, Quanshen Shen, Fanhong Wu , Na2S2O4 initiated free radical additions of polyfluoroalkyl halides to 4-pentenamides。 J. Fluorine chem. 2007, 128, 540-544.
7. Xueyan Yang, Zhonghua Wang, Xiang Fang, Xianjin Yang, Fanhong Wu, Yongjia Shen, Synthesis of Difluoromethylene-Containing 1,2,4-Oxadiazole Compounds via the Reaction of 5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole with Unsaturated Compounds initiated by Sodium Dithionite. Synthesis 2007, 17 68-1778.
8. Xueyan Yang, Zhonghua Wang, Yaoping Zhu, Xiang Fang, Xianjin Yang, Fanhong Wu,Yongjia Shen, Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives. J. Fluorine Chem. 2007, 128, 1046-1051.
9. Xiang Fang, Xueyan Yang, Xianjin Yang, Shenjie Mao, Zhonghua Wang,Guorong Chen and Fanhong Wu, AIBN-initiated radical addition of gem-difluorinated alkyl iodides to alkynes and the Pd-catalyzed Sonogashira coupling reaction of E-phenyl difluoromethylene vinylic iodides with terminal alkynes. Tetrahedron 2007, 63, 10684-10692.
10. Xianjin Yang, Wenjiao Yuan, Song Gu, Xueyan Yang, Fanhua Xiao, Quanshen Shen, Fanhong Wu，The Na2S2O4 initiated free radical additions of polyfluoroalkyl halides to 4-pentenamides，J. Fluorine Chem. 2007，128, 540–544.
11. Xueyan Yang, Xiang Fang, Xianjin Yang, Min Zhao, Yizheng Han, Yongjia Shen, Fanhong Wu. New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite. Tetrahedron, 2008, 64, 2259-2269.
12. Xiang Fang, Qi Ying, Yang Chen, Xueyan Yang ,Xianjin Yang, Fanhong Wu, Synthesis of fluoroalkyl-δ-lactones from polyfluoroalkyl iodides and 5-hexenoic acids, J. Fluorine Chem. 2008, 129, 280-285.
13. Xiang Fang, Yang Chen, Daming He, Xianjin Yang, Fanhong Wu, Synthesis and substitution reactions of b-alkoxyvinyl bromodifluoromethyl ketones, J. Fluorine Chem. 2008, 129, 1167-1172.
14. Xiang Fang, Xueyan Yang，Min Zhao, Qingfeng Di, Xiaoguang Wang, Fanhong Wu，One-pot synthesis of 4,4-difluoro-3-oxo-2-(triphenyl phosphoranylidene)-dlactones by Reformatsky reaction, J. Fluorine Chem. 2009, 130, 974-978.
15. Xueyan Yang, Shengxia Shui, Xi Chen, Hai’ou He, Fanhong Wu*, “Syntheisis of bromodifluoromethyl substituted pyrazoles and isoxazoles”, J. Fluorine Chem., 2010, 131, 426-432.
16. Xueyan Yang, Xianjin Yang*, Wei Pan, Ying Wang, Wei Cai, Fanhong Wu*, “Stereoselective cycloaddition–lactonization reaction of 2-allyl-4- pentenoic acids with polyfluoroalkyl iodides. An efficient synthesis of polyfluoroalkyl-containing bicyclolactone derivatives”, Tetrahedron, 2010, 66, 7288-7294.
Part-time Doctoral tutor of East China University of Science and Technology
Links: http://hyxy.ecust.edu.cn/new/viewProf.php?id=446