
吴小梅,女,副教授,理学博士,硕士生导师,办公地点:第三学科楼C202,邮箱:wuxiaomei@sit.edu.cn。
主要研究方向:手性医药与精细化学品的绿色生物合成新技术,及高附加值化学品的绿色合成产业化开发。
近五年科研项目:主持横向项目:头孢噻肟的合成新工艺研究(27220H200028001-A06)。
近五年代表性论文及授权专利:
1. Songshuang Cao, Xiaomei Wu*, Baodi Ma, Yi Xu*. Highly Efficient Asymmetric Synthesis of Aliphatic Chiral Secondary Alcohols by Whole Cells of E. coli Co-Expressing Alcohol Dehydrogenase and Glucose Dehydrogenase.Catalysis Letters (2025) 155:131.
2. Wenyu Peng, Xiaomei Wu, Baodi Ma* and Yi Xu* Enhancement of the Thermostability of Microbacterium Esterase by Combinatorial Rational Design. Molecules 2024, 29, 5839.
3. 侯现莉, 吴小梅*, 马宝娣, 徐毅*. 敏捷食酸菌腈水解酶在大肠杆菌中的组成型表达及其催化高浓度烟腈水解的研究. 分子催化(中英文),2024,38:560.
4. Kaixin Wei, Xiaomei Wu*, Baodi Ma, Zhi Li, Yi Xu*. Facile immobilization of his-tagged Microbacterial esterase on Ni-SBA-15 with enhanced stability for efficient synthesis of key chiral intermediate of d-biotin. Bioproc Biosyst Eng, 2022, 45:1075.
5. Xin-Yi Lu, Xiaomei Wu, Baodi Ma* and Yi Xu*. Enhanced thermostability of Pseudomonas nitroreducens isoeugenol monooxygenase by the combinatorial etrategy of surface residue replacement and consensus mutagenesis. Catalysts, 2021, 11, 1199.
6. Song He, Xiaomei Wu*, Baodi Ma, Zhi Li, Yi Xu*.High specific immobilization of His‑tagged recombinant Microbacterium esterase by Ni-NTA magnetic chitosan microspheres for efficient synthesis of key chiral intermediate of d-biotin. Bioproc Biosyst Eng, 2021, 44: 2193.
7. Qian Wang, Xiaomei Wu, Xinyi Lu et al. Efficient Biosynthesis of Vanillin from Isoeugenol
by Recombinant Isoeugenol Monooxygenase from Pseudomonas nitroreducens Jin1. Applied Biochemistry and Biotechnology, 2021, 193:1116.
8. 徐毅,王自稳,吴小梅,马宝娣等。一种重组表达载体、基因工程菌及菌的培养方法和应用。ZL202111269631.X,2024-8-27授权。
9. 徐毅, 吴小梅, 刘明春等,一种水性涂料催干剂及其制备方法。ZL201910496717.2,2022-08-05授权。
10. 吴小梅,马宝娣,徐毅. 思政引领下的化工制药类研究生协同培养模式探究。广东化工,2022, 49,223-224.
获奖与荣誉:
2014年11月,获得上海应用技术大学第七届青年教师讲课竞赛优秀奖。