
马宝娣,女,工学博士(华东理工大学),副教授,硕士生导师。主要从事生物催化相关研究。办公地点:第三学科楼A309,邮箱:mabaodi2005@163.com。
近年主持科研项目:
(1).醇氧化酶的对映选择性改造及其催化手性伯醇氧化机制研究,国家自然科学基金青年项目,2022.01-2024.12。
(2).异丁香酚单加氧酶分子改造及其催化合成天然香兰素的研究,生物催化与酶工程国家重点实验室开放课题,2019.01-2020.12。
(3).头孢曲松和头孢噻肟的合成新工艺研究,企业合作项目,2023.5-2024.5。
代表性论文:
1.Baodi Ma*, Xudong Kong*, Structural studies of NAD+-dependent methanol dehydrogenase 1
from Bacillus methanolicus MGA3, Acta Crystallographica Section D-structural Biology, 2025,
D81: 646-655.
2. Baodi Ma, Jiayi Li, Jianhe Xu, Tao Yu, Xudong Kong*, ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus, Journal of Biological Chemistry, 2025, 301(9): 110599.
3.Chenghai Sun#, Baodi Ma#, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong*, Xudong Qu*. Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines, Angew. Chem. Int. Ed. 2023, e202304994.
4.Wenyu Peng, Xiaomei Wu, Baodi Ma*, Yi Xu*, Enhancement of the thermostability of Microbacterium esterase by combinatorial rational design. Molecules 2024, 29: 5839.
5.Jia Wu, Baodi Ma*, Yi Xu*. One-pot synthesis of β-alanine from maleic acid via three-enzyme cascade biotransformation. Catalysts. 2023, 13: 267.
6.Qian Wang, Xiaomei Wu, Xinyi Lu; Yucai He, Baodi Ma*, Yi Xu*, Efficient biosynthesis of vanillin from isoeugenol by recombinant isoeugenol monooxygenase from pseudomonas nitroreducens jin1, Appl. Biochem. Biotech. 2021, 193:1-13.