任玉杰:联系邮箱:clab@sit.edu.cn
上海应用技术大学教授,1965年生,东北师范大学本科和硕士学位、大连理工大学博士学位、大连化学物理研究所博士后、加拿大滑铁卢大学访问学者。先后在大连理工大学和华东理工大学工作,2005年至今担任教授,受聘2013-2017教育部高等学校大学化学课程教学指导委员会委员。
以第一作者或通讯作者在J. Org. Chem., Green Chem.,Eur. J. Med. Chem.等国内外学术刊物上发表研究论文60余篇,申请中国发明专利40项。完成国家、上海市和企业的科研项目多项。已培养毕业研究生30余人。主要研究方向:1. 计算机辅助药物分子的设计、合成和活性研究2. 精细化学品的合成研究3. 有机中间体的合成和工艺研究
代表性科研项目:
1.国家自然科学基金:大气压下介质阻挡放电制备负载型纳米TiO2光催化剂
2.国家自然科学基金:卟啉类衍生物LB膜在气体传感器方面的应用研究
3.上海市教委科研创新重点项目:白藜芦醇与达比加群酯活性中间体拼合产物的合成与生物活性研究
4.上海市科委生物医药领域产学研合作项目:达比加群酯关键中间体产业化工艺研究
5.多项企业委托课题
代表性论文与专利:
1. Molecular modeling, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors.Bioorganic & Medicinal Chemistry,2016, 24,73-84
2.Design, synthesis, biological evaluation and molecular docking studies of dabigatran analogs as potential thrombin inhibitors, J IRAN CHEM SOC,2016,13:347–357
3.Synthesis and biological evaluation of novel dabigatran derivatives as thrombin inhibitors.Res Chem Intermed,2016, 42:735–752
4.Design, synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitorsEur.J.Med.Chem., 2015,96, 122- 138
5. Design, synthesis, biological evaluation and molecular docking of novel dabigatran derivatives as potential thrombin inhibitors,RSC Advances.2015,5,23737- 23748
6.Molecularmodeling studies of dihydro-alkyloxy- benzyl-oxopyrimidines(DABOs)as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase using 3D- QSAR, Topomer CoMFA and molecular docking simulations. RSC Advances. 2015, 5, 13754-13756
7.Identification of triazolo[4,5-b]pyrazine derivatives as hepatocyte growth factor receptor inhibitors through structure–activity relationships and molecular docking simulations. Bioorganic & Medicinal Chemistry Letters,2015,25, 4118-4126
8.Molecular modeling studies of [6,6,5] Tricyclic Fused Oxazolidinones as FXa inhibitors using 3D-QSAR, Topomer CoMFA, molecular docking and molecular dynamics simulations.Bioorganic & medicinal chemistry letters, 2015, 25(20), 4522–4528
9.Triflic acid adsorbed on silica gel as an efficient and recyclable catalyst for the addition of b-dicarbonyl compounds to alcohols and alkenes. Green Chem.2010, 12, 1049-1055
10.Perchloric Acid-Catalyzed Homogeneous and Heterogeneous Addition of β-Dicarbonyl Compounds to Alcohols and Alkenes and the Investigation of the Mechanism J. Org. Chem.2010, 6. 5017-5030