甘莉: 联系邮箱：ganli@sit.edu.cn
上海应用技术大学的副研究员、硕导，2009.07毕业于中国药科大学药剂学专业的博士。主要从事功能性纳米载体的设计及其在眼组织转运和生物效应机理的研究。曾担任中科院上海药物研究所药物制剂研究中心副研究员、硕士生导师，国家药监局药品审评中心的外聘专家。
目前，主持或参与了国家973计划、863计划（2007AA021604）、国家自然科学基金（81102387）、上海市科委（11ZR1444700）等多项项目，在Biomaterials、Drug Discovery Today国内外学术期刊发表论文20余篇，申请新型专利12项，其中PCT专利1项，获授权专利6项。作为主要技术执行人设计研发了具备仿生特点的功能性眼用脂质载体制剂，先后完成了2类新药环孢素A眼用乳剂等多项眼用新型制剂，并协助企业建成了国内首条自动化眼用乳剂生产线。中科院青年创新促进会会员，上海药物所首届“新星计划 A类”人才，曾获2012年中国药学会“第十一届全国青年药学工作者最新科研成果交流会”优秀论文三等奖。
代表性科研项目：
1.国家自然科学基金——透明质酸修饰的眼用核-壳纳米组装体的设计及对炎症组织靶向性的研究（81102387），负责人
2.上海市科委自然科学基金——CD44介导的眼用核-壳纳米组装体的设计及对顽固性葡萄膜炎抑制机理的研究（11ZR1444700），负责人
3.国家重大科学研究计划（973计划）——纳米技术改善难溶性药物功效的应用基础研究（2009CB90330），技术骨干
4.国家高技术研究发展计划（863计划）——眼部上皮多肽给药制剂的研究（2007AA021604），技术骨干
5.上海市科委登山行动计划——环孢素眼用乳剂的研究（064319006-2），技术骨干
代表性论文与专利：
1.Li Gan, Jing Wang, Yanan Zhao, Dan Chen, Chunliu Zhu, Jianping Liu, Yong Gan*. Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection. Biomaterials 2013,34:5978-5987.
2.Li Gan, Jing Wang, Min Jiang, Hanah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Yong Gan*. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov. Today 2013,18:290-297. 受邀综述
3.Li Gan, Yiping Gao, Chunliu Zhu, Xinxin Zhang, Yong Gan. Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption. J. Pharm. Sci. 2013,102:1752-1759
4.Min Jiang, Li Gan (Co-first author), Chunliu Zhu, Yang Dong, Jianping Liu, Yong Gan*. Cationic core-shell liponanoparticles for ocular gene delivery. Biomaterials 2012,33: 7621-7630.
5.Jinqiu Shen, Li Gan (Co-first author), Chunliu Zhu, Xinxin Zhang, Yang Dong, Min Jiang, Jiabi Zhu, Yong Gan*. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect. Int. J. Pharm. 2011,412: 115-122.
6.Li Gan, Shun Han, Jinqiu Shen, Chunliu Zhu, Xinxin Zhang, Yong Gan*. Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: improving preocular retention and ocular bioavailability. Int. J. Pharm. 2010, 396 (1-2): 179-187.
7.Li Gan, Yong Gan*, Chunliu Zhu, Xinxin Zhang, Jiabi Zhu. Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results. Int. J. Pharm. 2009, 365 (1-2): 143-149.
8.Shun Han, Jinqiu Shen, Yong Gan, Xinxin Zhang, Chunliu Zhu, Li Gan*. Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen: Low irritancy and higher bioavailability. Acta Pharmacol. Sin. 2010, 31: 990-998.
9.Hongzhen Yu, Sifei Han, Ping Li, Chunliu Zhu, Xinxin Zhang, Li Gan, Yong Gan*. An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione. J. Pharm. Sci. 2011,100(11):5048-5058.
10.Yiping Gao, Chunliu Zhu, Xinxin Zhang, Li Gan, Yong Gan*. Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. J.Microencapsul. 2011,28(6):549-556.
11.Ping Li, Chun-liu Zhu, Xinxin Zhang, Li Gan, Hongzhen Yu, Yong Gan*. Reversible Inhibitory Effects of Saturated and Unsaturated Alkyl Esters on the Carboxylesterases Activity in Rat Intestine. Lipids.2010, 45(7):603-612
12.Ping Li, Hongzhen Yu, Xinxin Zhang, Li Gan, Chunliu Zhu, Yong Gan*. Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion. Acta Pharmacol. Sin. 2010,31(7):881-888
13.Shiyan Guo, Xinxin Zhang, Li Gan, Chunliu Zhu, Yong Gan*. Effect of PEO-PPO-PEO micelles on pharmacokinetics and intestinal toxicity of CPT-11: Potential Involvement of BCRP (ABCG2). J. Pharm. Pharmacol. 2010.62：973-984
14.Sifei Han, Tingting Yao, Xinxin Zhang, Li Gan, Chunliu Zhu, Hongzhen Yu, Yong Gan*. Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation. Int. J. Pharm. 2009, 379: 18-24
15.Zhen Ge, Xinxin Zhang, Li Gan, Yong Gan*. Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability. Acta Pharmacol. Sin. 2008, 29: 990-997.
16.Xinxin Zhang, Weisan Pan, Li Gan, Chunliu Zhu, Yong Gan*. Effects of BCRP inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of camptothecin analogues. Acta Pharmacol. Sin. 2008, 29: 1391-1398
17.Xinxin Zhang, Yong Gan, Li Gan, Shufang Nie, Weisan Pan*. PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer. J. Pharm. Pharmacol.2008, 60: 1077-1087
18.Xinxin Zhang, Weisan Pan, Li Gan, Yong Gan*，Shufang Nie. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spay-drying. Chem. Pharm. Bull. 2008, 56: 1645-1650
19.Huijun Xie, Yong Gan*, Suwei Ma, Li Gan. Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network. Drug Dev. Ind. Pharm. 2008, 34: 363-372.
20.赵亚男，甘莉，王静，陈熙，贾征，甘勇，刘建平. 透明质酸修饰的核壳纳米粒对视网膜色素上皮细胞基因转染效率的研究药学学报 2014,49 (5):711-717
21.王静，甘莉，甘勇，刘建平. 透明质酸修饰的地塞米松核壳纳米粒的制备及表征. 中国药科大学学报 2013,44(2):117-123
22.蒋敏，甘莉，甘勇，刘建平*.新型眼用脂质载体制剂的研究进展. 中国药科大学学报2012,47(16),1265-1269.
23甘莉，危军，甘勇*，Degenhard Marx，李健. 新的疫苗技术——鼻腔疫苗, 中国医药工业杂志. 2010, 41(4), 298-304.
24.沈锦秋，甘勇，甘莉，朱春柳，朱家壁*. 氟比洛芬酯眼用纳米乳-离子敏感原位凝胶的研究药学学报. 2010, 45(1), 120-125.
25.马守伟，甘勇，甘莉，朱春柳，朱家壁*. 新型眼用阳离子微乳－原位凝胶的制备及体外角膜滞留特性的研究. 药学学报.2008, 43, 749-755.
26.林艳琼，甘勇，甘莉，王柏，陈欣欣*. 地塞米松眼用微乳的研究. 中国药学杂志.2006, 41(5), 358-362
专利：
1.甘勇，甘莉，朱春柳氟比洛芬酯眼用纳米乳-原位凝胶制剂及其制备方法 ZL 200810202017.X
2.甘勇，甘莉，栾琳等具有相转变性质的扎那米韦鼻用原位凝胶剂及其制备方法 ZL 200810033452.4
3.甘勇，甘莉，韩顺一种表皮生长因子眼用脂质纳米载体原位凝胶制剂 ZL 200710040729.1
4.甘勇，甘莉，马守伟等眼用微乳/亚微乳原位凝胶制剂及其制备方法，ZL 200710038667.0
5.甘勇，甘莉，王昕等一种环孢菌素A眼用微乳制剂及其制备方法. ZL 200510024644.5
6.甘勇，甘莉，王昕等一种微乳型人工泪液. ZL 200510026876.4
7.GAN YONG, GAN LI, ZHU CHUNLIU Flurbiprofen axetil eye nano-emulsion in-situ gel preparation and preparation method thereof PCT/CN2009/001211
8.朱家壁，甘莉，甘勇地塞米松眼用纳米立方液晶制剂及其制备方法 200910119062.3
9.甘勇，甘莉，马守伟，朱春柳一种环孢菌素A眼用微/亚微乳原位凝胶制剂及其制备方法，200710037662.6
10.甘勇，张馨欣，甘莉等扎那米韦鼻用纳米混悬剂及其制备方法 200910045077.X
11.甘勇，张馨欣，甘莉等皮肤用表皮生长因子纳米脂质载体制剂及其制备方法 200910044855.3
12.甘勇，甘莉，吕伟等 10-羟基-9-烯丙基喜树碱的注射制剂及它的制备方法 200510028291.6