上海应用技术大学药物创新研究所

发布时间:2016-04-20浏览次数:1833

吴晶晶:联系方式:wujj@sit.edu.cn

上海应用技术大学化学与环境工程学院制药工程专业副教授,硕士生导师。分别于2007年和2012年在华东理工大学药学院获得学士和博士学位。2012年起在上海应用技术大学化学与环境工程学院制药工程专业从事科研与教学工作。

以主要作者在国内外核心学术杂志如Chem CommunAdv Synth CatalChemCatChemJ Org ChemRSC AdvEur. J Org ChemTetrahedronOrg Biomol ChemJ Fluorine Chem等发表多篇论文;申请中国发明专利多项。现指导硕士研究生多名。研究方向:1.  碳氟键的活化及官能团化2.  含氟药物及含氟农药的设计与合成研究3.  新含氟砌块的设计及含氟化合物的合成方法学研究

代表性科研项目:

1.负责国家自然科学基青年基金项目一项:金属催化的烯烃上碳氟键的还原及烷()基化

2.参与国家自然科学基金面上项目一项偕二氟取代Combretastatins衍生物的设计与合成

3.负责若干项横向项目。

代表性论文与专利:

1.      Jingjing Wu*, Juan Xiao, Wenpeng Dai, Song Cao*. Synthesis of monofluoroalkenes through selective hydrodefluorination of gem-difluoroalkenes with Red-Al®. RSC Advances, 2015, 5, 34498–34501.

2.      Yang Xiong, Tao Huang, Xinfei Ji, Jingjing Wu*, Song Cao*. Nickel-catalyzed Suzuki–Miyaura type cross coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids. Org. Biomol. Chem., 2015, 13, 7389–7392.

3.      Jiexiong Wang, Jingjing Wu*, Heng Chen, Shaowu Zhang, Fanhong Wu*. Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids. Chin. Chem. Lett., 2015, 26, 1381–1384.

4.      Lili Yan, Jingjing Wu*, Heng Chen, Shaowu Zhang, Zhi Wang, Hui Wang, Fanhong Wu*. Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones, RSC Advances, 2015, 5, 73660–73669.

5.      Jingjing Wu*, Dan Fu, Song Cao*. Synthesis of polyfluoroaryl-containing 1,2,3-triazoles by reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters. J. Fluorine chem., 2014, 168, 230-235.

6.      Wenpeng Dai, Juan Xiao, Guanyi Jin, Jingjing Wu*, Song Cao*. Palladium- or Nickel-catalyzed Kumada Cross-coupling Reaction of gem-Difluoroalkenes and Monofluoroalkenes with Grignard Reagents. J. Org. Chem., 2014, 79, 10537–10546.

7.      Jingjing Wu, Wenwen Zhao, Song Cao*. Novel synthesis of difluoromethyl-containing α-acyloxycarboxamide derivatives via Passerini reaction and desulfonylation. European J. Org. Chem., 2012, 1380-1387.

8.      Jingjing Wu, Song Cao*. Nickel-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydride (Lithium Triethylborohydride). ChemCatChem, 2011, 3, 1582-1586.

9.      Jingjing Wu, Jianhang Cheng, Jian Zhang, Hui Li, Mingxi Wu, Li Shen, Xuhong Qian, Song Cao*. Non-catalytic conversion of C-F bonds of gem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydride under room temperature. Tetrahedron, 2011, 67, 285-288.

10.    Jian Zhang, Jingjing Wu, Yang Xiong, Song Cao*. Synthesis of unsymmetrical biaryl ethers through nickel-promoted coupling of polyfluoroarenes with arylboronic acids and oxygen. Chem. Commun., 2012, 48, 8553-8555.

11.    Wenwen Zhao, Jingjing Wu, Song Cao*. Highly efficient NiCl2/NiCl2(PCy3)2 co-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydride. Adv. Synth. Catal., 2012, 354, 574-578.