上海应用技术大学药物创新研究所教师资料（排名不分先后）
吴范宏（所长）：联系邮箱：wfh@sit.edu.cn
上海应用技术大学教授，1968年3月生，浙江东阳人。博士、教授，博士生导师。上海市政协委员、民进上海市委委员。中国化学会和美国化学会会员、中国药学会高级会员；《中国化学快报》通讯编委，《Tetrahedron》、《Tetrahedron Letter》、《应用化学》、《化学学报》和《有机化学》等杂志的审稿专家。1995年，毕业于中国科学院上海有机化学研究所有机化学专业获得理学博士学位。1997年成为复旦大学化学系的博士后。1997–2009年间在华东理工大学化学与分子工程学院，教授，博导。2009年10月至今，上海应用技术大学化学与环境工程学院院长（至2014年11月），上海应用技术大学药物创新研究所所长。2013年7月至3014年3月，加拿大滑铁卢大学化学工程系高级访问学者。
多年来潜心教学、悉心育人，带领团队开展科学研究和技术开发工作，培养了大量的科研人才。已在国内外发表高水平研究论文140多篇，SCI收录论文44篇。申请发明专利61项，已授权9项。已指导毕业硕士研究生100余名、博士研究生10多名、工程硕士20名及国内外进修教师多名。
2012年被评为上海市优秀学术带头人（制药工程），获得 “上海市育才奖”。 2013年被评为制药工程领域的上海市优秀学术带头人。基于在氟化学和药物合成方面做出的杰出贡献，还获得“科学中国人（2013）年度人物”-杰出青年科学家奖。2014年带领团队获得上海市科技进步奖三等奖，并获得第二十六届上海市优秀发明选拔赛优秀发明奖。2014年带领的上海应用技术学院制药工程团队获得上海市总工会的“教育先锋号”称号。同时，担任2014年中国化学会第十三届全国氟化学会议主席，该会议取得圆满成功。
主要研究领域包括：有机氟化学基础研究、手性含氟药物以及含氟生物活性物质的合成研究；新药研发及仿制药创新工艺研究、医药原料药及其中间体的合成工艺过程和绿色生产工艺研究等。科研工作颇具特色，在有机氟化学基础研究、新药研发及药物创新合成工艺等领域取得了丰硕成果。
代表性科研项目：
1.国家自然科学基金“新型氟代HMG-CoA还原酶抑制剂的设计与合成”
2.国家自然科学基金“偕二氟取代Combretastatins衍生物的设计与合成”
3.上海市科促会联盟计划”肿瘤血管靶向破坏剂新药物——乙氧基二苯乙烷及其衍生物的开发和工艺改进”
4.多项企业委托课题
代表性论文与专利:
1.Ding Mei , Yan Yin*, Fanhong Wu, Jiaxing Cui , Hong Zhou , Guofeng Sun, Yu Jiang , Yangbo Feng. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor’s potency and ROCK2/PKA selectivityby 3D-QSAR, molecular docking and molecular dynamics simulations. Bioorganic & Medicinal Chemistry 2015, 23, 2505–2517.
2.Yan Yin*, Hong Zhou, Xichen Liu, Haiying Chen , Fanhong Wu, Heng Zhang , Ruiheng Tao, Fengkai Cheng, Yangbo Feng. A metal-free and recyclable synthesis of benzothiazoles using thiourea as a sulfur surrogate. Tetrahedron Letters 2015, 56, 1709–1712.
3.Lei Zhao, Jiu-Jiu Zhou, Xin-Ying Huang, Li-Ping Cheng, Wan Pang *, Zhen-Peng Kai *, Fan-Hong Wu*. Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs. Chinese Chemical Letters 2015, 26, 993–999
4.Jiexiong Wang, Jingjing Wu*, Heng Chen, Shaowu Zhang, Fanhong Wu*. Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids. Chin. Chem. Lett., 2015, 2015, 26,1381–1384.
5.Lili Yan, Jingjing Wu*, Heng Chen, Shaowu Zhang, Zhi Wang, Hui Wang, Fanhong Wu*. Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones, RSC Advances, 2015,5, 73660–73669.
6.Peng Liu, Zhenjiang Liu, Fanhong Wu. Highly Regio- and Diastereoselective Addition of Organolithium Reagents to Chiral Fluoroalkyl α,β-Unsaturated N-tert- Butanesulfinyl Ketimines, A General and Efficient Access to Tertiary Fluoroalkyl Allylic Amines and α-Fluoroalkyl α-Amino Acids. Advanced Synthesis & Catalysis. 2015, 357, 818-822.
7.Qianqian Lv , Zhi Wang , Zhonghua Wang , Fanhong Wu, Liping Cheng . 3D-QSAR and Docking Studies on 2-acyliminobenzimidazoles Derivatives as Potent ALK Inhibitors.Letters in Drug Design & Discovery. 2015, 12, 219-233.
8.Jinju Chen, Chuanxiang Liu, Fengjie Guan, Chuanxiu Zhang, Kai Ji, Xinyu Wang, Min Xu, Fanhong Wu. Derivatives of α,α-aryl Naphthalimide Nitriles as Fluoride ion Sensors, Convenient Precursors for the Synthesis of Aryl Naphthalimide.synlett. 2015, 26, 6109-6112.
9.Yan Yin*, Guofeng Sun, Heng Zhang, Hong Zhou, Fanhong Wu. Enatioselective Chalcogeno-Baylis-Hillman Reaction of Benzaldehydes with MVK and Acrylates Catalyzed by Chiral Thiepin-TiCl4 Complex. Chin. J. Chem. 2014, 32, 365-369.
10.Zhi Wang, Liping Cheng, Zhenpeng Kai, Fanhong Wu, Zhuoyu Liu , Minfeng Cai. Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.Bioorganic & Medicinal Chemistry Letters. 2014, 24, 3869–3876.
11.Chao Fang, Fanhong Wu. The research for introducing gem-difluoromethylene group into the organic molecules.Advanced Materials Research . 2014, 881-883, 196-200.
12.Chao Fang, Yan Yin, Heng Zhang, Fanhong Wu. Enantioselective Reformatsky Reaction between Cinnamaldehyde and Diflurinated Organozinc Reagent, Synthesis of Chiral γ,γ-difluoro-β-hydroxy Esters as Precursors of Statin Analogs.Advanced Materials Research . 2014, 881-883, 154-158.
13.Yuanyuan Xing*, Chuanxiang Liu, Fanhong Wu*. Efficient synthesis of substituted imidazo[4, 5-b] pyridines.Heterocycl. Commun.. 2013, 19, 327-330.
14.Jinju Chen, Chuanxiang Liu,* Jiali Zhang, Wen Ding, Min Zhou , Fanhong Wu*. A novel chemodosimeter for fluoride ions based on deprotonation of the C-H group followed by an autoxidative decyanation process.Chem. Comm. 2013, 49, 10814-10816.
15.Bo Yang, Xiang Fang, Min Zhao, Xueyan Yang*, Fanhong Wu*. Microwave-assisted Expeditious Synthesis of 5-fluoroalkyl-3-(aryl or alkyl)-oxazolidin-2-ones.Tetrehedron. 2013, 69, 3331-3337.
16.Xiaoguang Wang, Xiang Fang, Hongyuan Xiao, Dongming Gong, Xueyan Yang, Fanhong Wu. A new and direct route to 3-fluoromethyl substituted pyrazol-4-acrylates via Pd-catalyzed C-H activation.Tetrehedron. 2013, 69, 6993-7000.
17.Xueyan Yang, Xiang Fang*, Dong Zhang, Yanlin Yu, Zhengdong Zhang, Fanhong Wu*. Regioselective Nucleophilic Addition of 3-aryl-5-difluoromethyl-isoxazoles to Aldehydes.J. Fluorine Chem. 2013, 145, 1-7.
18.Ibrayim Saidalimu, Xiang Fang, Xiaopeng He, Jing Liang , Xueyan Yang, Fanhong Wu. Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α-Fluorinated gem-Diols to N-Benzyl Isatins.Angew. Chem. Int. Ed. 2013, 125, 5566-5570.
19.Ibrayim Saidalimu, Xiang Fang, Wenwen Lv, Xueyan Yang, Xiaopeng He, Jingyuan Zhang, Fanhong Wu. Organocatalytic Asymmetric Michael Addition/Carbon-Carbon Bond Cleavage of Trifluoromethyl a-Fluorinated gem-Diols to Nitroolefins.Adv. Synth. Catal. 2013, 355, 857-863.
20.肖繁花,吴范宏. 康布瑞汀磷酸酯二钠盐合成工艺的优化.有机化学. 2013, 33, 1564-1567.
21.陈梓湛,吴玉锋,郭杰,方超,吴范宏. 三氯异氰尿酸参与的水-甲醇可重复利用体系中的氯代反应.化学世界. 2013, 1, 26-29.
22.杨燕,周军全,姚跃良,吴范宏. 抗癫痫药左乙拉西坦的工艺优化新方法. 华东理工大学学报（自然科学版）.有机化学. 2013, 39.
23.杨波, 方向, 杨雪艳, 吴范宏. 一种有效合成5-氟烷基噁唑啉的方法.有机化学. 2013, 33, 1782-1790.
24.杨波,赵敏,方向,杨雪艳,吴范宏. 一种有效合成3-芳基-4-氟烷基-2-噁唑烷酮的方法.有机化学. 2013, 33, 1088-1095.
25.石璐燕,于燕燕,吴范宏. HPLC 法测定左乙拉西坦含量及其有关物质.化学试剂. 2013.
26.Chuangxiang Liu, Yong Chen, Yingxin Sun, Fanhong Wu. Crystal structure and mechanistic investigation of the reaction of 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)--1H-pyrazole-3-carbonitrile with unsaturated carbonyl compounds. 2013, 39, 2087-2093.
27.Xiaoguang Wang, Xiang Fang,* Xueyana Yang, Meng Ni, Fanhong Wu*. Synthesis of 1,3, 5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate]pyrazoles via a Pd-Catalyzed C-H Activation.Chinese journal of chemistry. 2012, 30, 2767-2773.
28.Guanlong Chen, Fuli Chen, YanZ hang, Xueyan Yang, Xiaoming Yuan, Fanhong Wu, Xianjin Yang. The investigation of fluorination reaction of p-substituted benzenesulfonimides with fluorine-nitrogen mixed gas to synthesize NFSI analogues.Journal of fluorine chmeistry. 2012, 133, 155-159.
29.Xiaoguang Wang, Xiang Fang, Hongyuan Xiao, Yan Yin, Huimin Xia, Fanhong Wu*. Synthesis of gamma, gamma-difluoro-beta-hydroxy-delta-lactones as new precursors of HMG-CoA reductase inhibitor.Journal of fluorine chmeistry. 2012, 133, 178-183.
30.位青聪,叶文涛,宋辉,吕雯雯,赵敏,吴范宏. β-萘甲醚合成新工艺.现代化工. 2012, 32.
31.邢媛媛,吴范宏. 3-胺基-丙基硼酸的合成.上海应用技术学院学报. 2012, 4, 288-290.
32.王东升,刘传祥,姚跃良,吴范宏. 制药工艺学课程教学内容与教学方式的探讨.广州化工. 2012, 40.
33.姚跃良,徐毅,王东升,樊冬丽,吴范宏. 制药工艺学课程教学内容与教学方式的探讨.广州化工. 2012, 40.
34.石璐燕,于燕燕,李兴,吴范宏. HPLC法测定左乙拉西坦右旋异构体及其原料药含量.上海应用技术学院学报. 2012, 12.
35.Xiang Fang , Ying Xiong , Qiong Wang , Min Zhao , Fanhong Wu. Synthesis of Fluoroalkylated Allylic-beta-hydroxyesters and Fluoroalkylated beta,Y-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate. Chinese journal of chemistry. 2011, 29, 2669-2674.
36.Saidalimu Ibrayim, Xiang Fang, Dong Zhang, Fanhong Wu*. A Green and Novel Method for the Synthesis of 4, 4-Difluoro-3-oxo-2-(triphenylphosphoranylidene) delta-Lactones by Reformatsky Reaction. Chinese journal of chemistry. 2011, 29, 2713-2716.
37.Xueyan Yang, Xiang Fang, Zhenghua Ju, Yunli Hu, Fanhong Wu*. One-Pot Addition-Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones .Synthesis-stuttgart. 2011, 22, 3627-3634.
38.Yingjun Xu, Fanhong Wu, Zhiyi Yao *, Minmin Zhang, Sheng Jiang.Synthesis of Quinoxaline 1,4-di-N-Oxide Analogues and Crystal Structure of 2-Carbomethoxy-3-hydroxyquinoxaline-di-N- oxide .Molecules. 2011, 16, 6894-6901.
39.Xueyan Yang,Tiemei Lü,Shengjie Zhu, Fanhong Wu. Fluoroalkylation of Chiral Enoic Acids Initiated by Sodium Dithionite .Acta chimica sinica. 2011, 69, 815-820.
40.Yaoping Zhu, Xueyan Yang, Xiang Fang, Xianjin Yang*, Lingling Ye, Wei Cai, Yan Zhang, Fanhong Wu*. Sodium dithionite initiated reaction of pent-4-en-1-amines with fluoroalkyl iodides for the synthesis of 2-fluoroalkyl pyrrolidine derivatives .Tetrahedron. 2011, 67, 1251-1257.
41.Xueyan Yang, Xianjin Yang, Shengjie Zhu, Lingling Ye, Yang Chen, Guanlong Chen, Fanhong Wu. Sodium Dithionite Initiated Addition-lactonization of 2-Acylamino-4-pentenoic Acids with Fluoroalkyl Iodides to Synthesize 4-Fluoroalkyl-2-acylamino-4-butyrolactones .Chinese jounal of chemistry. 2010, 28, 2269-2273.
42.Xueyan Yang, Xianjin Yang, Wei Pan, Ying Wang, Wei Cai, Fanhong Wu. Stereoselective cycloaddition-lactonization reaction of 2-allyl-4-pentenoic acids with polyfluoroalkyl iodides. An efficient synthesis of polyfluoroalkyl-containing bicyclolactone derivatives.Tetrahedron. 2010, 66, 7288-7294.
43.唐婷,杨雪艳,陈曦,吴范宏. Synthesis of Fluoroalkyl Substituted Biphenol A Derivatives .Chemical jounral of chinese universities-chinese. 2010, 31, 1179-1183.
44. Ting Tang, Xueyan Yang, Fanhong Wu. Synthesis of Several Fluorine-containing Monomers and Their Polymerization Reaction .Acta chimica sinica. 2010, 68, 803-808.
45.XueYan Yang, ShengXia Shui, Xi Chen, Haiou He, FanHong Wu. Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles .Journal of fluorine chmeistry. 2010, 131, 426-432.
